Template-directed reactions of aminonucleosides.
We have studied the reactions between adenosine 5'-phosphorimidazolide and 9-(2-amino-2-deoxyxylofuranosyl) adenine (I) or 3'-methylamino-3'-deoxy-adenosine (II), both with and without a poly (U) template. We find that both amino compounds react much more rapidly than does adenosine, in the absence of a template. The rate of reaction is greatly enhanced by a poly (U) template in the case of I, but the enhancement is slight in the case of II.
4 references, click to expand
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Hydrolytic stability of helical RNA: a selective advantage for the natural 3',5'-bond.Proc Natl Acad Sci U S A. 1976 Apr;73(4):1149-53 PMID: 1063396
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Template-directed synthesis of high molecular weight polynucleotide analogues.Nature. 1976 May 27;261(5558):342-4 PMID: 1272416
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Nucleosides from 3-deoxy-3-methylamino-D-ribofuranose.J Org Chem. 1970 Nov;35(11):3808-14 PMID: 5474326
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Polymerization of nucleotide analogues I: reaction of nucleoside 5'-phosphorimidazolides with 2'-amino-2'-deoxyuridine.J Mol Evol. 1976 May 26;7(4):253-67 PMID: 933177
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