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PMID: 3023885 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An active chromatin structure acquired by translocated c-myc genes.

Molecular and cellular biology ·Vol. 6 ·No. 4 ·1986-04-00 ·Pages 1357-61

Kakkis E, Prehn J, Calame K

Abstract

We used general sensitivity to DNase I digestion to analyze the chromatin structure of c-myc genes in seven murine plasmacytomas. In every case, the 3' portion of c-myc juxtaposed with C alpha displayed a much more DNase I-sensitive chromatin structure than untranslocated c-myc or, in one case analyzed, the reciprocally translocated 5' portion. Our data suggest the presence of regulatory sequences near the C alpha gene segment.

MeSH Terms
Animals Chromatin/physiology Cloning, Molecular DNA Restriction Enzymes Mice Oncogenes Plasmacytoma/genetics
Chemicals
Chromatin DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kakkis E
Prehn J
Calame K
References (46)
46 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.6.4.1357-1361.1986
Published
1986-04-00
Pages
1357-61
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367653
Subset
IM
Grants
NIGMS NIH HHS · GM-07104 · United States
NCI NIH HHS · N01-CB-25584 · United States
External Links
PubMed source DOI: 10.1128/mcb.6.4.1357-1361.1986 PMC Full Text View journal details
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