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PMID: 3024106 Published · ppublish English Journal Article

The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.

Nucleic acids research ·Vol. 14 ·No. 21 ·1986-11-11 ·Pages 8413-26

MacLeod AR, Houlker C, Reinach FC, Talbot K

Abstract

We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.

MeSH Terms
Amino Acid Sequence Base Sequence Cloning, Molecular DNA Restriction Enzymes Fibroblasts/metabolism Genes Humans Protein Biosynthesis RNA, Messenger/genetics Reticulocytes/metabolism Transcription, Genetic Tropomyosin/genetics
Chemicals
RNA, Messenger Tropomyosin DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
MacLeod A R
Houlker C
Reinach F C
Talbot K
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29 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.21.8413
Published
1986-11-11
Pages
8413-26
Language
English
Region
England
NLM ID
0411011
PMCID
PMC311868
Subset
IM
Databases
GENBANK
X04588
External Links
PubMed source DOI: 10.1093/nar/14.21.8413 PMC Full Text View journal details
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