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PMID: 3024169 Published · ppublish English Comparative Study Journal Article

Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 23 ·1986-12-00 ·Pages 9188-92

Reiher WE, Blalock JE, Brunck TK

Abstract

A region of homology has been found between the envelope (env) protein of the acquired immunodeficiency syndrome (AIDS) virus and a portion of interleukin 2 (IL-2) that purportedly binds to the IL-2 receptor. This homology, between two proteins associated with opposing biological functions, suggests possible mechanisms for the immunosuppressive activity of the AIDS virus. Two mechanisms are proposed in which the AIDS virus env protein interferes with IL-2 activity either directly or indirectly. A region of similarity to the purported IL-2 receptor binding site on IL-2 and AIDS virus env is present in the env proteins of other retroviruses associated with immunosuppression. A synthetic peptide vaccine for AIDS is suggested based on the IL-2 receptor binding sequence in AIDS virus env.

MeSH Terms
Amino Acid Sequence Binding Sites Chromosome Mapping DNA Restriction Enzymes Genes, Viral HIV/genetics Interleukin-2/genetics,metabolism Receptors, Immunologic/metabolism Receptors, Interleukin-2 Viral Envelope Proteins/genetics
Chemicals
Interleukin-2 Receptors, Immunologic Receptors, Interleukin-2 Viral Envelope Proteins DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Reiher W E
Blalock J E
Brunck T K
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.23.9188
Published
1986-12-00
Pages
9188-92
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC387100
Subset
IM
Databases
GENBANK
M14668, M14669, M14670, M14671, M14672, M14673
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1073/pnas.83.23.9188 PMC Full Text View journal details
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