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PMID: 3027359 Published · ppublish English Journal Article

Glucocorticoid regulation of murine leukemia virus transcription elements is specified by determinants within the viral enhancer region.

Journal of virology ·Vol. 61 ·No. 2 ·1987-02-00 ·Pages 269-75

Celander D, Haseltine WA

Abstract

The transcriptional control region (the long terminal repeat, LTR) of the leukemogenic murine retrovirus SL3-3 contains a glucocorticoid-responsive consensus sequence, as does the corresponding region of the nonleukemogenic virus Akv. Dexamethasone increases gene expression directed by both LTR sequences. However, the responses of the LTRs of the two viruses to dexamethasone differ according to the cell line in which the response is measured. The results of these studies provide insights regarding differences in response to glucocorticoids dependent upon cell line and indicate that the glucocorticoid-responsive elements may compose one of the determinants of tissue specificity and pathogenicity of the murine retroviruses.

MeSH Terms
Base Sequence Dexamethasone/pharmacology Enhancer Elements, Genetic/drug effects Genes, Regulator/drug effects Genes, Viral/drug effects HeLa Cells/metabolism Humans Leukemia Virus, Murine/drug effects,genetics Plasmids Progesterone/pharmacology Transcription, Genetic/drug effects Transfection
Chemicals
Progesterone Dexamethasone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Celander D
Haseltine W A
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.2.269-275.1987
Published
1987-02-00
Pages
269-75
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253946
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.61.2.269-275.1987 PMC Full Text View journal details
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