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PMID: 3027388 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A mutant of herpes simplex virus type 1 exhibits increased stability of immediate-early (alpha) mRNAs.

Journal of virology ·Vol. 61 ·No. 2 ·1987-02-00 ·Pages 604-6

Oroskar AA, Read GS

Abstract

vhs1 is a herpes simplex virus type 1 mutant defective in the shutoff of both host and alpha polypeptide synthesis. In cycloheximide reversal experiments, alpha mRNAs were significantly more stable in vhs1-infected cells than in cells infected with wild-type virus, whether assayed by in vitro translation or Northern blotting.

MeSH Terms
Animals Cycloheximide/pharmacology Immediate-Early Proteins Kinetics Mutation RNA, Messenger/genetics Simplexvirus/drug effects,genetics Vero Cells Viral Proteins/genetics
Chemicals
IE1 protein, Human herpesvirus 1 Immediate-Early Proteins RNA, Messenger Viral Proteins Cycloheximide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oroskar A A
Read G S
References (23)
23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.2.604-606.1987
Published
1987-02-00
Pages
604-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253989
Subset
IM
Grants
NIAID NIH HHS · AI21501 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.2.604-606.1987 PMC Full Text View journal details
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