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PMID: 3038004 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

More than one DNA sequence encodes the 2''-O-adenylyltransferase phenotype.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 4 ·1987-04-00 ·Pages 667-70

Lee SC, Cleary PP, Gerding DN

Abstract

Biochemical and phenotypic assays indicate that three enterobacterial R plasmids isolated in a single hospital encode 2''-O-adenylyltransferase [ANT(2'')], and an ANT(2'')-specific probe was developed from one plasmid. Southern hybridization revealed the three plasmids to be unrelated and, further, showed their ANT(2'')-encoding genes to be different.

MeSH Terms
Bacterial Proteins/genetics DNA, Bacterial/genetics Enterobacteriaceae/genetics,isolation & purification Enterobacteriaceae Infections/microbiology Genes Genes, Bacterial Humans Nucleotide Mapping Nucleotidyltransferases/genetics Phenotype R Factors Sequence Homology, Nucleic Acid
Chemicals
Bacterial Proteins DNA, Bacterial Nucleotidyltransferases gentamicin 2''-nucleotidyltransferase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lee S C
Cleary P P
Gerding D N
References (18)
18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.31.4.667
Published
1987-04-00
Pages
667-70
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC174806
Subset
IM
Grants
NHLBI NIH HHS · 1T32HL107114 · United States
NIAID NIH HHS · AI6722 · United States
External Links
PubMed source DOI: 10.1128/AAC.31.4.667 PMC Full Text View journal details
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