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PMID: 3038753 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Identification of a specific receptor for plasmin on a group A streptococcus.

Infection and immunity ·Vol. 55 ·No. 8 ·1987-08-00 ·Pages 1914-8

Lottenberg R, Broder CC, Boyle MD

Abstract

Certain group A streptococci demonstrate surface receptors that bind selectively to the key fibrinolytic enzyme, plasmin. These bacteria show no reactivity with the zymogen protein plasminogen or with other serine class proteases, such as trypsin or urokinase. Bacterium-bound plasmin retains its ability to cleave synthetic substrates and its ability to hydrolyze a fibrin clot. The bacterium-bound plasmin is not effectively regulated by its physiological regulator, alpha 2-plasmin inhibitor. This study is the first report of a bacterium-associated receptor for plasmin.

MeSH Terms
Fibrinolysin/metabolism Plasminogen/metabolism Receptors, Cell Surface/metabolism Streptococcus pyogenes/metabolism Trypsin/metabolism Urokinase-Type Plasminogen Activator/metabolism alpha-2-Antiplasmin/metabolism
Chemicals
Receptors, Cell Surface alpha-2-Antiplasmin Plasminogen Trypsin Fibrinolysin Urokinase-Type Plasminogen Activator
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lottenberg R
Broder C C
Boyle M D
References (20)
20 references, click to expand
  1. Mechanisms of cell and tissue injury induced by group A streptococci: relation to poststreptococcal sequelae.
    J Infect Dis. 1972 Oct;126(4):419-56 PMID: 4563791
  2. Analysis of surface receptor expression on bacteria isolated from patients with endocarditis.
    J Gen Microbiol. 1986 Jul;132(7):2049-52 PMID: 2947970
  3. Studies on the active center of human plasmin. Partial amino acid sequence of a peptide containing the active center serine residue.
    J Biol Chem. 1969 Jul 10;244(13):3590-7 PMID: 4240117
  4. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs.
    Arzneimittelforschung. 1983;33(4):479-94 PMID: 6191764
  5. Isolation and partial characterization of a type II Fc receptor from a group A streptococcus.
    Mol Cell Biochem. 1986 Apr;70(1):57-66 PMID: 3520293
  6. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.
    Cancer Res. 1981 Nov;41(11 Pt 1):4629-36 PMID: 6458354
  7. The identification of fibrinopeptide B as a chemotactic agent derived from human fibrinogen.
    Br J Haematol. 1974 Aug;27(4):669-77 PMID: 4472824
  8. Detection of receptors for the Fc region of IgG on streptococci.
    J Immunol Methods. 1983 Apr 15;59(1):83-94 PMID: 6187866
  9. Effects of enzymatic degradation on the subunit composition and biologic properties of human factor VIII.
    Blood. 1978 Feb;51(2):281-97 PMID: 145884
  10. Recurrent bacterial infections in children.
    N Engl J Med. 1984 May 10;310(19):1237-43 PMID: 6369141
  11. Isolation and characterization of type IIa and type IIb Fc receptors from a group A streptococcus.
    Scand J Immunol. 1986 Nov;24(5):549-57 PMID: 2947318
  12. THE EFFECT IN PATIENTS OF STREPTOCOCCAL FIBRINOLYSIN (STREPTOKINASE) AND STREPTOCOCCAL DESOXYRIBONUCLEASE ON FIBRINOUS, PURULENT, AND SANGUINOUS PLEURAL EXUDATIONS.
    J Clin Invest. 1949 Jan;28(1):173-90 PMID: 16695653
  13. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.
    J Biol Chem. 1969 Aug 25;244(16):4406-12 PMID: 5806584
  14. Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.
    Cancer Res. 1980 Sep;40(9):3222-7 PMID: 7000340
  15. Active site mapping of human and rat urinary kallikreins by peptidyl chloromethyl ketones.
    Arch Biochem Biophys. 1980 Jul;202(2):420-30 PMID: 6906193
  16. Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.
    J Biol Chem. 1976 Oct 10;251(19):5956-65 PMID: 134998
  17. On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture.
    Thromb Haemost. 1980 Jun 18;43(2):77-89 PMID: 6450468
  18. Plasminogen activators, tissue degradation, and cancer.
    Adv Cancer Res. 1985;44:139-266 PMID: 2930999
  19. Mechanism of activation of human plasminogen by streptokinase. Presence of active center in streptokinase-plasminogen complex.
    J Biol Chem. 1972 Mar 25;247(6):1683-91 PMID: 4258976
  20. The behavior of alpha2-plasmin inhibitor in fibrinolytic states.
    J Clin Invest. 1977 Aug;60(2):361-9 PMID: 68962
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.8.1914-1918.1987
Published
1987-08-00
Pages
1914-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260624
Subset
IM
Grants
NIAID NIH HHS · AI 30445 · United States
NHLBI NIH HHS · HL 32901 · United States
External Links
PubMed source DOI: 10.1128/iai.55.8.1914-1918.1987 PMC Full Text View journal details
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