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PMID: 304486 Published · ppublish English Journal Article

Influence of lithium upon the intracellular potential of frog skin epithelium.

The Journal of membrane biology ·Vol. 37 ·No. 3-4 ·1977-12-15 ·Pages 347-59

Nagel W

Abstract

The effect of Li upon the intracellular potential of frog skin (Rana esculenta) was investigated. In the range between 1 and 25 mM Li in the epithelial bathing solution, a semilogarithmic linear relationship between [Li] and intracellular potential under short circuit conditions was obtained. The intracellular potential at all [Li] is quantitatively sufficient to explain the previously reported accumulation of Li in the intracellular space of the frog skin epithelium (Leblanc, G. 1972. Pfluegers Arch. 337:1) on the basis of a passibe entrance step at the outer border. A reduction of the intracellular potential by Li is also observed in the presence of 6 mM Na in the epithelial bathing solution. Consequences regarding the mechanism of uptake of Na across the outer border of the frog skin are discussed.

MeSH Terms
Amiloride/pharmacology Animals Anura Electric Conductivity Electrophysiology Epithelium/physiology In Vitro Techniques Lithium/pharmacology Rana esculenta Skin Physiological Phenomena Sodium/metabolism
Chemicals
Amiloride Lithium Sodium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nagel W
References (23)
23 references, click to expand
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01940939
Published
1977-12-15
Pages
347-59
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01940939 View journal details
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