Previously unexplained HLA antigens of combined immunodeficiency disease due to Ia alloantigens.

The presence of extra reactions in the HLA typing of a combined immunodeficiency patient may be attributed to B-cell alloantibodies in the HLA typing sera. The presence of these reactions can be used to identify HLA sera containing B-cell antibodies for further B-cell studies. The alloantibodies in this study have some association with the HLA-D determinants and segregate with HLA in normal families.