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PMID: 304891 Published · ppublish English Journal Article

The action of acetylcholine on background conductance in frog atrial trabeculae.

The Journal of physiology ·Vol. 274 ·1978-01-00 ·Pages 381-96

Garnier D, Nargeot J, Ojeda C, Rougier O

Abstract

The action of acetylcholine (ACh) on membrane potential and currents in frog atrial muscle has been studied with a double sucrose gap technique. The results show the following. 1. ACh induces the development of an extra current, outward at the resting potential, which is dependent on the ACh concentration. 2. The preparation does not show any sign of desensitization. 3. The reversal potential of the current induced by ACh is between 0 and 20 mV more negative than the resting potential and behaves as a K electrode. 4. The mechanism of ACh-induced K conductance presents inward going rectification properties. 5. The delayed outward current is not affected by ACh. However the evolution of its tail current seems to indicate a process of K accumulation related to the ACh-induced current.

MeSH Terms
Acetylcholine/pharmacology Action Potentials/drug effects Animals Anura Atrial Function Electric Conductivity Heart/drug effects,physiology Heart Atria/drug effects In Vitro Techniques Membrane Potentials/drug effects Potassium/physiology Rana catesbeiana Rana esculenta
Chemicals
Acetylcholine Potassium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Garnier D
Nargeot J
Ojeda C
Rougier O
References (31)
31 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1978.sp012154
Published
1978-01-00
Pages
381-96
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1282497
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1978.sp012154 PMC Full Text View journal details
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