Abstract
We infused microgram quantities of active or inactive PMN elastase and cathepsin G into the renal arteries of rats. Both active and inactive elastase localized to the glomerular capillary wall equally, and in amounts that could be achieved physiologically in GN. However, elastase-perfused rats developed marked proteinuria (196 +/- 32 mg/24 h) compared with control rats receiving inactive elastase (19 +/- 2 mg/24 h, p less than 0.005). Similar results were seen with active and inactive cathepsin G. Neither elastase nor cathepsin G infusion was associated with histologic evidence of glomerular injury. We conclude that the PMN neutral serine proteinases elastase and cathepsin G can mediate marked changes in glomerular permeability in vivo due to their proteolytic activity, and thus, may contribute to the proteinuria observed in PMN-dependent models of GN.
MeSH Terms
Animals
Cathepsin G
Cathepsins/physiology
Fluorescent Antibody Technique
Kidney Diseases/enzymology,pathology
Kidney Glomerulus/pathology
Neutrophils/enzymology
Pancreatic Elastase/physiology
Proteinuria/etiology
Rats
Serine Endopeptidases
Chemicals
Cathepsins
Serine Endopeptidases
CTSG protein, human
Cathepsin G
Ctsg protein, rat
Pancreatic Elastase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Johnson R J
Department of Medicine, University of Washington, Seattle 98195.
Couser W G
Alpers C E
Vissers M
Schulze M
Klebanoff S J
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