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PMID: 3051381 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

DNA diagnostics--molecular techniques and automation.

Science (New York, N.Y.) ·Vol. 242 ·No. 4876 ·1988-10-14 ·Pages 229-37

Landegren U, Kaiser R, Caskey CT, Hood L

Abstract

Molecular biology has revolutionized the understanding of many aspects of human disease. Ongoing developments in DNA diagnostics--the analysis of disease at the nucleic acid level--will soon provide automated, rapid, and inexpensive analyses for DNA or RNA sequences associated with genetic, malignant, and infectious diseases. DNA diagnostics will also facilitate the identification of disease-associated genes at birth, thus creating new opportunities for preventive medicine.

MeSH Terms
Automation Base Sequence DNA/genetics DNA-Directed DNA Polymerase/metabolism Diagnosis Gene Amplification Humans Molecular Biology/methods Nucleic Acid Probes
Chemicals
Nucleic Acid Probes DNA DNA-Directed DNA Polymerase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Landegren U
Division of Biology, California Institute of Technology, Pasadena 91125.
Kaiser R
Caskey C T
Hood L
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1988-10-14
Pages
229-37
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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