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PMID: 3064853 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Induction of rat gastric damage by the endothelium-derived peptide, endothelin.

British journal of pharmacology ·Vol. 95 ·No. 4 ·1988-12-00 ·Pages 1011-3

Whittle BJ, Esplugues JV

Abstract

The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.

MeSH Terms
Animals Endothelins Endothelium, Vascular/physiology Gastric Mucosa/drug effects,pathology Gastrointestinal Hemorrhage/chemically induced Male Necrosis Peptides/pharmacology,physiology Rats Rats, Inbred Strains Stomach Ulcer/chemically induced Vasoconstrictor Agents/pharmacology
Chemicals
Endothelins Peptides Vasoconstrictor Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Whittle B J
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
Esplugues J V
References (5)
5 references, click to expand
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    Nature. 1981 Jul 30;292(5822):472-4 PMID: 7195986
  2. Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat.
    Br J Pharmacol. 1988 Jan;93(1):222-8 PMID: 3349230
  3. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.
    Br J Pharmacol. 1988 Jun;94(2):528-39 PMID: 2840160
  4. Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa.
    Prostaglandins. 1988 Feb;35(2):137-48 PMID: 2966419
  5. A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
    Nature. 1988 Mar 31;332(6163):411-5 PMID: 2451132
Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1988.tb11733.x
Published
1988-12-00
Pages
1011-3
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1854285
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1988.tb11733.x PMC Full Text View journal details
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