Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 5 ·1978-05-00 ·Pages 2439-42

von Boehmer H, Haas W, Jerne NK

Abstract

Female murine T cells can respond to the Y antigen of male cells by generating cytotoxic T-killer lymphocytes. Responsiveness is linked to several H-2 genes. Two types of low responders can be distinguished: the B10.A(5R) (H-2i5) strain, a low responder because it lacks Y-specific precursor T cells able to differentiate into cytotoxic T-killer cells; and the CBA/J (H-2k) strain, a low responder because it lacks Y-specific T-helper cells able to support differentiation of T-killer cell precursors. B10.A(5R) stem cells differentiating in an x-irradiated (CBA/J X C57BL/6) (H-2k X H-2b)F1 host respond to Y antigen by generating T-killer cells whereas CBA/J stem cells do not. The results are consistent with the hypothesis that diversity of T-cell receptors is generated by somatic mutation of germ-line genes encoding specificity for self-H-2. A detailed account of this hypothesis is presented.

MeSH Terms

Animals Binding Sites Cell Differentiation Cytotoxicity, Immunologic Female Genetic Linkage H-2 Antigens/genetics Killer Cells, Natural/immunology Lymphocyte Cooperation Male Mice Radiation Chimera T-Lymphocytes/immunology Thymus Gland/cytology,immunology Y Chromosome/immunology

Chemicals

H-2 Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

von Boehmer H

Haas W

Jerne N K

References (18)

18 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.5.2439

Published

1978-05-00

Pages

2439-42

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC392569

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.5.2439 PMC Full Text View journal details

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Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

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