Streptococcal tetracycline resistance mediated at the level of protein synthesis.
The mechanism of tetracycline resistance was examined in strains containing each of the three previously identified resistance determinants in Streptococcus spp. Uptake of tetracycline was measured in tetracycline-sensitive cells as well as in cells containing each of the three resistance determinants. In cells containing tetL, uptake was not observed. However, in sensitive cells and cells containing either tetM or tetN, tetracycline was accumulated approximately 25-fold against a concentration gradient. Furthermore, there was no evidence for modification of intracellular tetracycline recovered from sensitive, tetM, or tetN cells. Protein synthesis in extracts derived from organisms containing tetM or tetN was resistant to tetracycline. In contrast, extracts of sensitive and tetL cells were sensitive to tetracycline.
17 references, click to expand
-
Conservation and transformation of energy by bacterial membranes.Bacteriol Rev. 1972 Jun;36(2):172-230 PMID: 4261111
-
Cation transport and electrogenesis by Streptococcus faecalis. I. The membrane potential.J Membr Biol. 1972;8(1):27-44 PMID: 4628384
-
Accumulation of neutral amino acids by Streptococcus faecalis. Energy coupling by a proton-motive force.J Biol Chem. 1973 Aug 10;248(15):5225-33 PMID: 4129287
-
Accumulation of arsenate, phosphate, and aspartate by Sreptococcus faecalis.J Bacteriol. 1975 Apr;122(1):266-77 PMID: 47322
-
Phenotypic characterization of R-factor tetracycline resistance determinants.Genet Res. 1974 Dec;24(3):333-43 PMID: 4618215
-
Transport of tetracyclines through the bacterial cell membrane assayed by fluorescence: a study with susceptible and resistant strains of Staphylococcus aureus and Escherichia coli.Microbios. 1978;21(83):7-21 PMID: 375035
-
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.Proc Natl Acad Sci U S A. 1980 Jul;77(7):3974-7 PMID: 7001450
-
Tetracycline transport in Bacteroides fragilis.Antimicrob Agents Chemother. 1980 Oct;18(4):502-5 PMID: 7447414
-
Identification of tetracycline-resistant R-plasmids in Streptococcus agalactiae (group B).Antimicrob Agents Chemother. 1980 Nov;18(5):753-60 PMID: 7004347
-
Tetracycline resistance genes from Bacillus plasmid pAB124 confer decreased accumulation of the antibiotic in Bacillus subtilis but not in Escherichia coli.J Bacteriol. 1981 Mar;145(3):1417-20 PMID: 6782092
-
Plasmids, drug resistance, and gene transfer in the genus Streptococcus.Microbiol Rev. 1981 Sep;45(3):409-36 PMID: 6272080
-
Heterogeneity of tetracycline resistance determinants in Streptococcus.J Bacteriol. 1982 Mar;149(3):995-1004 PMID: 6801018
-
Susceptibility of ribosomes of the tetracycline-producing strain of Streptomyces aureofaciens to tetracyclines.FEBS Lett. 1983 Feb 7;152(1):125-30 PMID: 6404649
-
Streptococcus faecalis proton gradients and tetracycline transport.J Bacteriol. 1984 Apr;158(1):49-54 PMID: 6325398
-
Molecular cloning of tetracycline resistance genes from Streptomyces rimosus in Streptomyces griseus and characterization of the cloned genes.J Bacteriol. 1985 Mar;161(3):1010-6 PMID: 2982781
-
Stepwise acquisition of multiple drug resistance by beta-hemolytic streptococci and difference in resistance pattern by type.Antimicrob Agents Chemother. 1978 Mar;13(3):399-404 PMID: 400820
-
THE GROUP D STREPTOCOCCI.Bacteriol Rev. 1964 Sep;28:330-66 PMID: 14220658
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