Home LiteratureArticle Details
PMID: 3085090 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Influence of delayed immune reactions on human epidermal keratinocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 10 ·1986-05-00 ·Pages 3469-73

Kaplan G, Witmer MD, Nath I, Steinman RM, Laal S, Prasad HK, Sarno EN, Elvers U, Cohn ZA

Abstract

The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubled in 48-72 hr, and this was attributed to increases in both size and number of keratinocytes. In addition, the phenotype of the keratinocytes changed from Ia- to Ia+. Similar changes in keratinocyte Ia-antigen expression occurred in the epidermis overlying untreated tuberculoid leprosy and cutaneous leishmaniasis lesions, but not in lepromatous leprosy. We suggest that one or more epidermal growth factors may be generated in the course of a delayed immune reaction in the dermis.

MeSH Terms
Antigens, Bacterial Antigens, Differentiation, T-Lymphocyte Antigens, Protozoan/analysis Antigens, Surface/analysis Epidermis/immunology,pathology Histocompatibility Antigens Class II/analysis Humans Hypersensitivity, Delayed/immunology,pathology Leishmaniasis/immunology,pathology Leprosy/immunology,pathology Monocytes/immunology T-Lymphocytes/immunology
Chemicals
Antigens, Bacterial Antigens, Differentiation, T-Lymphocyte Antigens, Protozoan Antigens, Surface Histocompatibility Antigens Class II
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Kaplan G
Witmer M D
Nath I
Steinman R M
Laal S
Prasad H K
Sarno E N
Elvers U
Cohn Z A
References (31)
31 references, click to expand
  1. The stimulation of epidermal proliferation by a specific protein (EGF).
    Dev Biol. 1965 Dec;12(3):394-407 PMID: 5884352
  2. Human interferon-gamma induces expression of HLA-DR on keratinocytes and melanocytes.
    Arch Dermatol Res. 1985;277(4):270-5 PMID: 3923947
  3. Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.
    J Histochem Cytochem. 1974 Dec;22(12):1077-83 PMID: 4374474
  4. Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.
    Cell. 1975 Nov;6(3):317-30 PMID: 1052770
  5. Immunological aspects of leprosy--present status.
    Prog Allergy. 1978;25:211-42 PMID: 362429
  6. Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages.
    J Exp Med. 1980 Nov 1;152(5):1248-61 PMID: 6448907
  7. The keratinocyte as differentiated cell type.
    Harvey Lect. 1980;74:101-39 PMID: 6160118
  8. Regulation of murine macrophage Ia-antigen expression by products of activated spleen cells.
    J Exp Med. 1980 Dec 1;152(6):1734-44 PMID: 6450260
  9. Epidermal cell (keratinocyte)-derived thymocyte-activating factor (ETAF).
    J Immunol. 1981 Oct;127(4):1493-8 PMID: 6974195
  10. In situ identification of T lymphocyte subsets and HLA-DR expressing cells in the human skin tuberculin reaction.
    Clin Exp Immunol. 1982 Aug;49(2):325-30 PMID: 6751638
  11. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes.
    N Engl J Med. 1982 Dec 23;307(26):1593-7 PMID: 6216407
  12. Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli.
    J Exp Med. 1982 Dec 1;156(6):1665-76 PMID: 6217272
  13. T lymphocyte subsets in the skin lesions of patients with leprosy.
    J Am Acad Dermatol. 1983 Feb;8(2):182-9 PMID: 6219136
  14. Immunohistological analysis of delayed-type hypersensitivity in man.
    Cell Immunol. 1982 Dec;74(2):358-69 PMID: 6762253
  15. Distinct HLA-DR epitopes and distinct families of HLA-Dr molecules defined by 15 monoclonal antibodies (mAb) either anti-DR or allo-anti-Iak cross-reacting with human DR molecule. I. Cross-inhibition studies of mAb cell surface fixation and differential binding of mAb to detergent-solubilized HLA molecules immobilized to a solid phase by a first mAb.
    Eur J Immunol. 1983 Feb;13(2):106-11 PMID: 6187579
  16. T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies.
    Clin Exp Immunol. 1983 Mar;51(3):421-9 PMID: 6342880
  17. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages.
    J Exp Med. 1983 Jul 1;158(1):126-45 PMID: 6190974
  18. The cutaneous infiltrates of leprosy. A transmission electron microscopy study.
    J Exp Med. 1983 Oct 1;158(4):1145-59 PMID: 6352848
  19. Immune cell populations in cutaneous delayed-type hypersensitivity.
    J Exp Med. 1983 Oct 1;158(4):1227-42 PMID: 6604784
  20. Keratinocytes synthesize Ia antigen in acute cutaneous graft-vs-host disease.
    J Immunol. 1983 Dec;131(6):2741-5 PMID: 6417231
  21. The macrophage--versatile element of inflammation.
    Harvey Lect. 1981-1982;77:63-80 PMID: 6765033
  22. Effect of treatment on the cellular composition of cutaneous lesions in leprosy patients.
    Int J Lepr Other Mycobact Dis. 1984 Dec;52(4):496-500 PMID: 6336043
  23. An analysis of in vitro T cell responsiveness in lepromatous leprosy.
    J Exp Med. 1985 Sep 1;162(3):917-29 PMID: 3928804
  24. Reactivity of Langerhans cells with hybridoma antibody.
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2541-4 PMID: 6941307
  25. Cloned human interferon-gamma, but not interferon-beta or -alpha, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines.
    J Immunol. 1984 Jan;132(1):240-5 PMID: 6418799
  26. Immune-interferon (IFN-gamma), macrophage-activating factors (MAFs), and colony-stimulating factors (CSFs) secreted by T cell clones in limiting dilution microcultures, long-term cultures, and by T cell hybridomas.
    Immunol Rev. 1983;76:5-28 PMID: 6420330
  27. A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3).
    J Immunol. 1984 Apr;132(4):1900-5 PMID: 6199417
  28. HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes.
    Eur J Immunol. 1984 Apr;14(4):299-304 PMID: 6609821
  29. Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease.
    J Exp Med. 1984 Jun 1;159(6):1784-9 PMID: 6202820
  30. The demonstration of cell surface antigens on T cells, B cells and accessory cells in paraffin-embedded human tissues.
    J Immunol Methods. 1984 Dec 31;75(2):227-39 PMID: 6394650
  31. Classification of leprosy according to immunity. A five-group system.
    Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73 PMID: 5950347
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.10.3469
Published
1986-05-00
Pages
3469-73
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323537
Subset
IM
Grants
NIAID NIH HHS · AI07012-19S · United States
NCI NIH HHS · CA30198-05 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.10.3469 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2