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PMID: 3086483 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

The Journal of experimental medicine ·Vol. 163 ·No. 6 ·1986-06-01 ·Pages 1595-600

Nachman RL, Hajjar KA, Silverstein RL, Dinarello CA

Abstract

Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.

MeSH Terms
Cells, Cultured Endothelium/drug effects,metabolism Feedback Glycoproteins/biosynthesis Humans Infant, Newborn Interleukin-1/pharmacology Plasminogen Activators/antagonists & inhibitors Plasminogen Inactivators Recombinant Proteins/antagonists & inhibitors,pharmacology Tissue Plasminogen Activator/antagonists & inhibitors Umbilical Veins Urokinase-Type Plasminogen Activator/antagonists & inhibitors
Chemicals
Glycoproteins Interleukin-1 Plasminogen Inactivators Recombinant Proteins Plasminogen Activators Tissue Plasminogen Activator Urokinase-Type Plasminogen Activator
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nachman R L
Hajjar K A
Silverstein R L
Dinarello C A
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22 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.163.6.1595
Published
1986-06-01
Pages
1595-600
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188126
Subset
IM
Grants
NHLBI NIH HHS · HL18828 · United States
NHLBI NIH HHS · K 11 HLAM1442 · United States
NHLBI NIH HHS · K08 HL01352 · United States
External Links
PubMed source DOI: 10.1084/jem.163.6.1595 PMC Full Text View journal details
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