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PMID: 3086742 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Changing the identity of a transfer RNA.

Nature ·Vol. 321 ·No. 6067 ·1986-00-00 ·Pages 213-9

Normanly J, Ogden RC, Horvath SJ, Abelson J

Abstract

A leucine transfer RNA has been transformed into a serine transfer RNA by changing 12 nucleotides. This result indicates that a limited set of residues determine tRNA identity.

MeSH Terms

Amino Acyl-tRNA Synthetases/metabolism Anticodon Base Sequence Codon Escherichia coli/genetics Leucine Nucleic Acid Conformation Protein Biosynthesis RNA, Transfer/genetics,metabolism Serine Structure-Activity Relationship Substrate Specificity Suppression, Genetic

Chemicals

Anticodon Codon Serine RNA, Transfer Amino Acyl-tRNA Synthetases Leucine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Normanly J

Ogden R C

Horvath S J

Abelson J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/321213a0

Published

1986-00-00

Pages

213-9

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NIGMS NIH HHS · GM06965 · United States

NIGMS NIH HHS · GM32637 · United States

NIGMS NIH HHS · T32GM07616 · United States

External Links

PubMed source DOI: 10.1038/321213a0 View journal details

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Changing the identity of a transfer RNA.

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