aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.
RJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The human class II-positive phenotype is restored in somatic cell hybrids between RJ 2.2.5 and mouse spleen cells. By karyotype and molecular studies of an informative family of hybrids we have now shown that the reexpression of human class II gene products, as well as the maintenance of the mouse class II-positive phenotype, correlates with the presence of mouse chromosome 16. Thus, the existence on this mouse chromosome of a newly found locus, designated by us aIr-1, that determines a trans-acting activator function for class II gene expression, is established. Possible implications of this finding are discussed.
12 references, click to expand
-
Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma.Proc Natl Acad Sci U S A. 1985 Aug;82(15):5145-9 PMID: 3875096
-
Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.J Exp Med. 1985 Oct 1;162(4):1117-33 PMID: 3862745
-
Ia-negative B-cell variants reveal a coordinate regulation in the transcription of the HLA class II gene family.Immunogenetics. 1984;19(4):349-53 PMID: 6609124
-
Non-random chromosome gains in human lymphoblastoid cell lines.Nature. 1977 Nov 24;270(5635):349-51 PMID: 201860
-
Sequences of mouse immunoglobulin light chain genes before and after somatic changes.Cell. 1978 Dec;15(4):1133-44 PMID: 103630
-
Analysis of the structural heterogeneity and polymorphism of human Ia antigens. Four distinct subsets of molecules are coexpressed in the Ia pool of both DR1,1 homozygous and DR3,W6 heterozygous B cell lines.J Exp Med. 1984 Feb 1;159(2):378-93 PMID: 6420499
-
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.J Immunol. 1981 Jan;126(1):317-21 PMID: 6935293
-
Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.J Exp Med. 1981 Apr 1;153(4):793-800 PMID: 6265582
-
Paired H-2-specific monoclonal antibodies react differently to red cells and lymphocytes.Immunogenetics. 1981 Dec;14(6):497-505 PMID: 7319569
-
Epitopic analysis of detergent-solubilized HLA molecules by solid-phase radioimmunoassay.J Immunol Methods. 1982 Oct 15;54(1):9-22 PMID: 6183366
-
Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets.J Exp Med. 1983 Mar 1;157(3):1053-8 PMID: 6403646
-
Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids.Biochem Genet. 1979 Feb;17(1-2):23-34 PMID: 454358
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
