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PMID: 3090396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.

Life sciences ·Vol. 39 ·No. 7 ·1986-08-18 ·Pages 645-50

Scofield AM, Fellows LE, Nash RJ, Fleet GW

Abstract

Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

MeSH Terms

Alkaloids/pharmacology Animals Chemical Phenomena Chemistry Disaccharidases/antagonists & inhibitors Female Imino Furanoses In Vitro Techniques Indolizines Intestinal Mucosa/enzymology Intestines/enzymology Mannitol/analogs & derivatives Mice Pyrrolidines Swainsonine

Chemicals

Alkaloids Imino Furanoses Indolizines Pyrrolidines Mannitol 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine Disaccharidases castanospermine Swainsonine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Scofield A M

Fellows L E

Nash R J

Fleet G W

Article Info

Journal

Life sciences

Abbr.

Life Sci

ISSN

0024-3205

DOI

10.1016/0024-3205(86)90046-9

Published

1986-08-18

Pages

645-50

Language

English

Region

Netherlands

NLM ID

0375521

Subset

External Links

PubMed source DOI: 10.1016/0024-3205(86)90046-9 View journal details

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Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.

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