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PMID: 3090771 Published · ppublish English Journal Article

Hepatic vascular endothelial cells heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes.

Virchows Archiv. A, Pathological anatomy and histopathology ·Vol. 409 ·No. 4 ·1986-00-00 ·Pages 407-16

Nagura H, Koshikawa T, Fukuda Y, Asai J

Abstract

During studies of the antigenic and functional properties of hepatic sinusoidal lining cells in situ, we found that only the sinusoidal endothelial cells share antigens with a peripheral blood macrophage subset capable of presenting soluble antigens and triggering autologous mixed lymphocyte reactions. They were HLA-DR+, OKM1-, OKM5+. Vascular endothelial cells in the portal areas and central veins were HLA-DR+, OKM1- and OKM5-. The sinusoidal endothelial cells also expressed an antigen found on helper/inducer (OKT4 and Leu3 a) T lymphocytes. Thus, the present study suggests that endothelial cells in different anatomic compartments in the liver heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes and possess distinct immunological functions.

MeSH Terms
Antibodies, Monoclonal Antigens, Surface/immunology Blood Vessels/cytology,immunology HLA-DR Antigens Histocompatibility Antigens Class II/analysis Histocytochemistry Humans Immunochemistry Liver Circulation Macrophages/immunology Monocytes/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antigens, Surface HLA-DR Antigens Histocompatibility Antigens Class II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nagura H
Koshikawa T
Fukuda Y
Asai J
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26 references, click to expand
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Article Info
Journal
Virchows Archiv. A, Pathological anatomy and histopathology
Abbr.
Virchows Arch A Pathol Anat Histopathol
ISSN
0174-7398
DOI
10.1007/BF00705413
Published
1986-00-00
Pages
407-16
Language
English
Region
Germany
NLM ID
8302198
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00705413
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