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PMID: 3091507 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Recombinant human gamma interferon inhibits simian malaria.

Infection and immunity ·Vol. 53 ·No. 3 ·1986-09-00 ·Pages 628-30

Maheshwari RK, Czarniecki CW, Dutta GP, Puri SK, Dhawan BN, Friedman RM

Abstract

Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.

MeSH Terms
Animals Female Interferon-gamma/therapeutic use Macaca mulatta Malaria/prevention & control Male Recombinant Proteins/therapeutic use
Chemicals
Recombinant Proteins Interferon-gamma
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Maheshwari R K
Czarniecki C W
Dutta G P
Puri S K
Dhawan B N
Friedman R M
References (19)
19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.53.3.628-630.1986
Published
1986-09-00
Pages
628-30
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260838
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.53.3.628-630.1986 PMC Full Text View journal details
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