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PMID: 3094439 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Comparative trial of single-dose ciprofloxacin and ampicillin plus probenecid for treatment of gonococcal urethritis in men.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 2 ·1986-08-00 ·Pages 267-9

Roddy RE, Handsfield HH, Hook EW

Abstract

In a double-blind comparative trial, 100 men with uncomplicated gonorrhea caused by beta-lactamase-negative Neisseria gonorrhoeae were treated with a single 0.25-g dose of ciprofloxacin administered orally or with 3.5 g of ampicillin plus 1.0 g of probenecid administered orally. Urethral infection was eradicated in all 49 men treated with ciprofloxacin and in 47 (92%) of 51 men treated with ampicillin-probenecid (P = 0.12). The geometric mean MICs for pretreatment isolates were 0.008 microgram of ciprofloxacin per ml, 0.09 microgram of penicillin G per ml, 0.52 microgram of tetracycline per ml, and 23.5 micrograms of spectinomycin per ml. Chlamydia trachomatis infection persisted in 10 of 11 men treated with ciprofloxacin and in 11 of 14 men treated with ampicillin-probenecid. A single 0.25-g dose of ciprofloxacin was effective for treatment of uncomplicated urethral gonorrhea in men, but it did not eradicate coinfection with C. trachomatis.

MeSH Terms
Adolescent Adult Ampicillin/therapeutic use Chlamydia Infections/complications,drug therapy Chlamydia trachomatis/drug effects Ciprofloxacin/therapeutic use Clinical Trials as Topic Double-Blind Method Drug Therapy, Combination Gonorrhea/complications,drug therapy Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Probenecid/therapeutic use Urethritis/drug therapy
Chemicals
Ciprofloxacin Ampicillin Probenecid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Roddy R E
Handsfield H H
Hook E W
References (18)
18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.30.2.267
Published
1986-08-00
Pages
267-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180532
Subset
IM
Grants
NIAID NIH HHS · AI-12192 · United States
External Links
PubMed source DOI: 10.1128/AAC.30.2.267 PMC Full Text View journal details
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