Norfloxacin in the therapy of uncomplicated gonorrhea.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 3 ·1986-09-00 ·Pages 514-5

Romanowski B, Wood H, Draker J, Tsianco MC

Abstract

In an open study, 70 patients with uncomplicated anogenital Neisseria gonorrhoeae infection were evaluated to determine the efficacy and safety of a single oral dose of norfloxacin (800 mg). Norfloxacin cured all 31 male urethral and 25 endocervical infections. All 63 isolates of N. gonorrhoeae tested were inhibited by 0.05 microgram of norfloxacin per ml.

MeSH Terms

Child Female Gonorrhea/drug therapy,microbiology Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Norfloxacin/adverse effects,therapeutic use

Chemicals

Norfloxacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Romanowski B

Wood H

Draker J

Tsianco M C

References (10)

10 references, click to expand

Single doses of methacycline and doxycycline for gonorrhea: a cooperative study of the frequency and cause of treatment failure.
J Infect Dis. 1973 Apr;127(4):461-6 PMID: 4632883
Evaluation of the Phadebact Gonococcus Test for confirmation of Neisseria gonorrhoeae.
J Clin Microbiol. 1980 Jul;12(1):15-7 PMID: 6775005
Comparative in vitro activity of Mk-0366 and other selected oral antimicrobial agents against Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 1981 Aug;20(2):265-6 PMID: 6456692
Comparative in-vitro activity of norfloxacin and selected antimicrobial agents against urinary tract pathogens and Neisseria gonorrhoeae.
J Antimicrob Chemother. 1982 Dec;10(6):553-7 PMID: 6219085
The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans.
Antimicrob Agents Chemother. 1985 Nov;28(5):716-21 PMID: 2936302
In vitro activities of ciprofloxacin, norfloxacin, pipemidic acid, cinoxacin, and nalidixic acid against Chlamydia trachomatis.
Antimicrob Agents Chemother. 1984 Jan;25(1):123-4 PMID: 6230988
Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin.
N Engl J Med. 1984 Jul 19;311(3):137-40 PMID: 6234465
In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 1984 Oct;26(4):608-9 PMID: 6240224
The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.
Antimicrob Agents Chemother. 1985 Oct;28(4):581-6 PMID: 3000292
Norfloxacin disposition after sequentially increasing oral doses.
Antimicrob Agents Chemother. 1983 Feb;23(2):284-8 PMID: 6220672

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.30.3.514

Published

1986-09-00

Pages

514-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC180593

Subset

External Links

PubMed source DOI: 10.1128/AAC.30.3.514 PMC Full Text View journal details

Analysis Services

Norfloxacin in the therapy of uncomplicated gonorrhea.

Contact

WeChat Official Account