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PMID: 309826 Published · ppublish English Journal Article

Inhibition of vitamin A action in rat bone cultures by inhibitors of RNA and protein synthesis.

Experientia ·Vol. 34 ·No. 9 ·1978-09-15 ·Pages 1159-61

Kistler A

Abstract

Using explanted humeri of late fetal rats, retinoic acid induced a dose- and time-dependent regression of cartilage. The retinoic acid-induced release of proteoglycan into the medium was blocked by inhibitors of RNA and protein synthesis, suggesting its dependence upon continuous RNA and protein synthesis.

MeSH Terms
Amanitins/pharmacology Bone Resorption/drug effects Bone and Bones/drug effects,metabolism Cycloheximide/pharmacology DNA/metabolism Dactinomycin/pharmacology Deoxyadenosines/pharmacology Organ Culture Techniques Proteins/metabolism Proteoglycans/metabolism RNA/metabolism Transcription, Genetic/drug effects Tretinoin/antagonists & inhibitors Vitamin A/analogs & derivatives
Chemicals
Amanitins Deoxyadenosines Proteins Proteoglycans Vitamin A Dactinomycin Tretinoin RNA DNA Cycloheximide
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kistler A
References (23)
23 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01922930
Published
1978-09-15
Pages
1159-61
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01922930
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