Immune suppression in vivo with antigen-modified syngeneic cells. I. T-cell-mediated suppression to the terpolymer poly-(Glu, Lys, Phe)n.
The palmitoyl derivative of the linear polypeptide of poly-(L-Glu-L-Lys-L-Phe)n (GLphi) can be coupled to spleen cells directly. The intravenous administration of 2 X 10(5)--3 X 10(7) GLphi-coupled syngeneic spleen cells induces GL-phi-specific suppressor T cells in C57BL/6 nonresponder mice. The suppression is antigen specific and can be detected by the inhibition of the primary GLphi plaque-forming cell response to challenge with GLphi-fowl gamma globulin. The number of inducer cells required for suppression carry less than 0.1 microgram of antigen. Spleen cells from tolerized mice can transfer suppression to normal syngeneic recipients. The suppression is cyclophosphamide sensitive and the suppressor cells bear the Thy 1.2 marker. This method of inducing antigen-specific suppressor cells may be generally applicable to other antigen systems.
17 references, click to expand
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The induction of hapten-specific T cell tolerance by using hapten-modified lymphoid cells. I. Characteristics of tolerance induction.J Immunol. 1976 Nov;117(5 Pt 1):1519-26 PMID: 1087316
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Mechanisms of regulation of cell-mediated immune responses. I. Effect of the route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picryl chloride.J Immunol. 1978 May;120(5):1604-11 PMID: 659864
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Paralysis to serum albumins in T and B lymphocytes in mice. Dose dependence, specificity and kinetics of escape.Eur J Immunol. 1974 Feb;4(2):120-5 PMID: 4546876
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Genetic control of specific immune suppression. IV. Responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide.J Exp Med. 1976 Jul 1;144(1):277-81 PMID: 1084407
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Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.J Exp Med. 1976 Apr 1;143(4):906-18 PMID: 1082920
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Complementation of H-2-linked Ir genes in the mouse.Proc Natl Acad Sci U S A. 1975 Sep;72(9):3671-5 PMID: 1059157
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Development of a hemolytic plaque assay for glutamic acid, lysine-containing polypeptides: demonstration that nonresponder mice produce antibodies to these peptides when conjugated to an immunogenic carrier.J Immunol. 1977 Sep;119(3):901-5 PMID: 70477
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Tolerance induced by TNP-derivatized syngeneic erythrocytes: evidence for cooperation between hapten-specific T and hapten-specific B lymphocytes in the immune response.J Immunol. 1978 Mar;120(3):844-9 PMID: 75928
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Presence of common idiotypes on antibodies induced by glutamic acid-lysine-containing terpolymers in responder and nonresponder mice with the Ig-1b heavy chain allotype.Eur J Immunol. 1977 Dec;7(12):865-71 PMID: 415884
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Role of self carriers in the immune response and tolerance. III. B cell tolerance induced by hapten-modified-self involves both active T cell-mediated suppression and direct blockade.Cell Immunol. 1978 May;37(2):327-35 PMID: 306890
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Regulation of antibody heterogeneity by suppressor T cells: diminishing suppressor T cell activity increases the number of dinitrophenyl clones in mice immunized with dinitrophenyl-poly(Glu,Lys,Phe) or dinitrophenyl-poly(Glu,Lys,Ala).Proc Natl Acad Sci U S A. 1978 Jun;75(6):2914-7 PMID: 307250
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Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.J Exp Med. 1978 Apr 1;147(4):1116-25 PMID: 306406
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Tolerance: two pathways of negative immunoregulation in contact sensitivity to DNFB.Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:105-11 PMID: 302184
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H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.J Exp Med. 1977 Apr 1;145(4):1071-6 PMID: 300774
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The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state.Eur J Immunol. 1977 Mar;7(3):165-70 PMID: 301091
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H-2 control of tolerance induction to L-glutamic acid, L-lysine-containing polymers.J Immunol. 1978 Oct;121(4):1370-5 PMID: 701799
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Suppression of contact sensitivity by T cells in the mouse. I. Demonstration that suppressor cells act on the effector stage of contact sensitivity; and their induction following in vitro exposure to antigen.Proc R Soc Lond B Biol Sci. 1974 Nov 5;187(1088):329-48 PMID: 4154454
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