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PMID: 309942 Published · ppublish English Journal Article

An analysis of the cable properties of frog ventricular myocardium.

The Journal of physiology ·Vol. 283 ·1978-10-00 ·Pages 263-82

Chapman RA, Fry CH

Abstract

1. The passive and active electrical parameters of frog ventricular myocardium have been measured. 2. The cytoplasmic resistivity has been determined by following changes in the resistance of a micro-electrode on penetration of a cell. 3. Unidimensional cable analysis using direct and alternating currents revealed the presence of a single time constant attributed to the surface membrane. 4. Longitudinal impedance measurements indicate that a second time constant is present in the intracellular pathway. 5. The results indicate that the resistance between cells is low so that action potentials can propagate from cell to cell by local circuits. 6. A three-dimensional cable analysis has also been carried out and compared to a simplified mathematical model which is presented in an Appendix and which closely approximates the experimental situation.

MeSH Terms
Action Potentials Animals Anura Cytoplasm/physiology Electric Conductivity Heart/physiology In Vitro Techniques Kinetics Membrane Potentials Rana pipiens Ventricular Function
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chapman R A
Fry C H
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34 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1978.sp012499
Published
1978-10-00
Pages
263-82
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1282776
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1978.sp012499 PMC Full Text View journal details
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