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PMID: 3102966 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.

Nature ·Vol. 325 ·No. 6106 ·1987-00-00 ·Pages 683-8

Borst J, van de Griend RJ, van Oostveen JW, Ang SL, Melief CJ, Seidman JG, Bolhuis RL

Abstract

Cloned blood lymphocytes that do not express the alpha- and beta-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the gamma-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex. These observations may help to solve the mystery posed by the discovery of the gamma gene.

MeSH Terms

Antigens, Differentiation, T-Lymphocyte Antigens, Surface/genetics,immunology Clone Cells/immunology Cytotoxicity, Immunologic Disulfides Gene Expression Regulation Humans Immunologic Deficiency Syndromes/immunology Macromolecular Substances RNA, Messenger/genetics Receptors, Antigen, T-Cell/genetics,immunology T-Lymphocytes/immunology

Chemicals

Antigens, Differentiation, T-Lymphocyte Antigens, Surface Disulfides Macromolecular Substances RNA, Messenger Receptors, Antigen, T-Cell

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Borst J

van de Griend R J

van Oostveen J W

Ang S L

Melief C J

Seidman J G

Bolhuis R L

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/325683a0

Published

1987-00-00

Pages

683-8

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NIAID NIH HHS · AI 18436 · United States

NIAID NIH HHS · AI 19148 · United States

External Links

PubMed source DOI: 10.1038/325683a0 View journal details

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A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.

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