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PMID: 3107462 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Norfloxacin versus thiamphenicol for treatment of uncomplicated gonorrhea in Rwanda.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 3 ·1987-03-00 ·Pages 434-7

Bogaerts J, Martinez Tello W, Verbist L, Piot P, Vandepitte J

Abstract

In an open prospective study, single oral doses of norfloxacin (800 mg) and thiamphenicol (2.5 g) were used to treat, respectively, 122 and 46 consecutive patients with uncomplicated gonorrhea. Neisseria gonorrhoeae was eradicated from 119 (97.5%) patients treated with norfloxacin and from 35 (76.0%) patients treated with thiamphenicol. Norfloxacin treatment failure was not related to drug resistance or to insufficient absorption of the drug. Thiamphenicol failure correlated with low in vitro susceptibility of the infecting strain. In a single oral dose of 800 mg, norfloxacin appeared to be an excellent alternative treatment regimen for uncomplicated gonorrhea in an area with a high prevalence of penicillin-resistant gonococci.

MeSH Terms
Female Gonorrhea/drug therapy Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Norfloxacin/therapeutic use Thiamphenicol/therapeutic use
Chemicals
Thiamphenicol Norfloxacin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bogaerts J
Martinez Tello W
Verbist L
Piot P
Vandepitte J
References (10)
10 references, click to expand
  1. Comparative in vitro activity of Mk-0366 and other selected oral antimicrobial agents against Neisseria gonorrhoeae.
    Antimicrob Agents Chemother. 1981 Aug;20(2):265-6 PMID: 6456692
  2. Treatment of uncomplicated gonorrhea with rosoxacin.
    Antimicrob Agents Chemother. 1981 Nov;20(5):625-9 PMID: 6798924
  3. Comparison of spectinomycin, cefuroxime, thiamphenicol, and penicillin G in the treatment of uncomplicated gonococcal infections in women.
    J Infect Dis. 1982 Apr;145(4):583 PMID: 6461702
  4. Rosoxacin in the therapy of uncomplicated gonorrhea.
    Antimicrob Agents Chemother. 1984 Apr;25(4):455-7 PMID: 6428307
  5. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin.
    N Engl J Med. 1984 Jul 19;311(3):137-40 PMID: 6234465
  6. A double blind study comparing two dosages of enoxacin for the treatment of uncomplicated urogenital gonorrhoea.
    J Antimicrob Chemother. 1984 Sep;14 Suppl C:91-4 PMID: 6438048
  7. In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae.
    Antimicrob Agents Chemother. 1984 Oct;26(4):608-9 PMID: 6240224
  8. Treatment of gonorrhea with single-dose thiamphenicol in Kenya.
    Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):376-8 PMID: 6441281
  9. Comparison of thiamphenicol and spectinomycin in the treatment of uncomplicated gonorrhea in men.
    Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):386-90 PMID: 6240786
  10. "One-minute treatment" with thiamphenicol in 50,000 cases of gonorrhea: a 22-year study.
    Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):391-5 PMID: 6523316
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.31.3.434
Published
1987-03-00
Pages
434-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC174746
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.31.3.434 PMC Full Text View journal details
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