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PMID: 3108448 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differentiation-linked secretion of urokinase and tissue plasminogen activator by normal human hemopoietic cells.

The Journal of experimental medicine ·Vol. 165 ·No. 6 ·1987-06-01 ·Pages 1609-23

Wilson EL, Francis GE

Abstract

Previous studies have shown that the response of patients with acute myeloid leukemia to induction chemotherapy can be predicted by the species of plasminogen activator that their cells secrete. Patients whose cells secreted tissue plasminogen activator (tPA) only failed to respond to combination chemotherapy. Individuals whose leukemic cells display features of the early progenitor phenotype also respond poorly to therapy. This suggested that the two species of plasminogen activator secreted by leukemic cells might be produced by normal cells at distinct stages of differentiation. These results indicate that the secretion of the two enzyme types is a differentiation-linked property of normal cells with tPA being produced by granulocyte/macrophage progenitors and urokinase by more differentiated cells and by mature neutrophils and macrophages.

MeSH Terms
Bone Marrow/metabolism Cell Differentiation Cells, Cultured Centrifugation, Density Gradient Hematopoietic Stem Cells/metabolism Humans Leukemia, Myeloid, Acute/drug therapy,metabolism,pathology Macrophages/metabolism Neutrophils/metabolism Plasminogen Activators/metabolism Tissue Plasminogen Activator/metabolism Urokinase-Type Plasminogen Activator/metabolism
Chemicals
Plasminogen Activators Tissue Plasminogen Activator Urokinase-Type Plasminogen Activator
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilson E L
Francis G E
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32 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.165.6.1609
Published
1987-06-01
Pages
1609-23
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188366
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.165.6.1609 PMC Full Text View journal details
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