Azulfidine- (sulfasalazine-) induced hepatic injury.

The American journal of digestive diseases ·Vol. 23 ·No. 10 ·1978-10-00 ·Pages 956-8

Kanner RS, Tedesco FJ, Kalser MH

Abstract

A patient with Azulfidine-related hepatotoxicity in which prompt recurrence of symptoms, fever skin rash, and laboratory evidence of hepatocellular injury occurred upon readministration of Azulfidine is reported. The clinical and biochemical features support the fact that this was an example of an acquired hypersensitivity reaction to Azulfidine.

MeSH Terms

Adolescent Alanine Transaminase Aspartate Aminotransferases Bilirubin/blood Chemical and Drug Induced Liver Injury Drug Hypersensitivity Female Humans Sulfasalazine/adverse effects Time Factors

Chemicals

Sulfasalazine Aspartate Aminotransferases Alanine Transaminase Bilirubin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kanner R S

Tedesco F J

Kalser M H

References (8)

8 references, click to expand

Granulomatous hepatitis associated with sulfadimethoxine hypersensitivity.
JAMA. 1967 Dec 4;202(10 ):985-8 PMID: 5630747
Focal hepatitis, fever and skin rash following therapy with sulfamethoxypyridazine, a long-acting sulfonamide.
N Engl J Med. 1958 Apr 3;258(14):687-90 PMID: 13526923
Sulfonamide-induced chronic liver disease.
Scand J Gastroenterol. 1974;9(1):93-6 PMID: 4453809
Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype.
N Engl J Med. 1973 Sep 6;289(10):491-5 PMID: 4146729
Adverse reactions to salicylazosulfapyridine (azulfidine) in the treatment of ulcerative colitis.
South Med J. 1968 Apr;61(4):354-8 PMID: 4384520
Sulfapyridine-induced serum-sickness-like syndrome associated with plasmacytosis, lymphocytosis and multiclonal gamma-globulinopathy.
N Engl J Med. 1969 Mar 6;280(10):547-8 PMID: 4179285
Sulfonamide hepatic injury. Review of the literature and report of a case due to sulfamethoxazole.
N Engl J Med. 1967 Oct 12;277(15):785-8 PMID: 6046676
Systemic granulomatous reaction to salicylazosulfapyridine (Azulfidine) in a patient with Crohn's disease.
Am J Dig Dis. 1974 May;19(5):465-9 PMID: 4151115

Article Info

Journal

The American journal of digestive diseases

Abbr.

Am J Dig Dis

ISSN

0002-9211

DOI

10.1007/BF01072475

Published

1978-10-00

Pages

956-8

Language

English

Region

United States

NLM ID

0404011

Subset

External Links

PubMed source DOI: 10.1007/BF01072475

Analysis Services

Azulfidine- (sulfasalazine-) induced hepatic injury.

Contact

WeChat Official Account