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PMID: 3115202 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Factor VIII related antigen in the assessment of vasculitis.

Annals of the rheumatic diseases ·Vol. 46 ·No. 6 ·1987-06-00 ·Pages 441-7

Woolf AD, Wakerley G, Wallington TB, Scott DG, Dieppe PA

Abstract

Factor VIII related antigen, an endothelial cell product, was markedly raised in systemic necrotising arteritis, reflecting disease activity, but was not raised in active cutaneous vasculitis. In rheumatoid arthritis high levels were only found in systemic vasculitis or Felty's syndrome, but in other connective tissue diseases increased levels were more frequently detected and usually related to disease activity. It did not correlate with C reactive protein. It was also raised in non-inflammatory peripheral vascular disease and after surgery and was not specific for vasculitic endothelial damage. Factor VIII related antigen may be useful in identifying and monitoring systemic necrotising and large vessel arteritis.

MeSH Terms
Antigens/analysis Arteritis/immunology Arthritis, Rheumatoid/immunology C-Reactive Protein/analysis Connective Tissue Diseases/immunology Enzyme-Linked Immunosorbent Assay Factor VIII/analysis,immunology Follow-Up Studies Humans Myositis/immunology Vascular Diseases/immunology Vasculitis/immunology von Willebrand Factor/analysis
Chemicals
Antigens von Willebrand Factor Factor VIII C-Reactive Protein
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Woolf A D
Wakerley G
Wallington T B
Scott D G
Dieppe P A
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39 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.46.6.441
Published
1987-06-00
Pages
441-7
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1002162
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.46.6.441 PMC Full Text View journal details
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