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PMID: 312013 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex.

American journal of human genetics ·Vol. 31 ·No. 1 ·1979-01-00 ·Pages 35-41

Raum D, Glass D, Carpenter CB, Schur PH, Alper CA

Abstract

Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meioses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.

MeSH Terms
Adult Alleles Arthritis, Rheumatoid/genetics Child Chromosome Mapping Complement C2/genetics Complement Factor B/genetics Crossing Over, Genetic Female Genes HLA Antigens/genetics Humans Major Histocompatibility Complex Male Pedigree Rheumatic Diseases/genetics
Chemicals
Complement C2 HLA Antigens Complement Factor B
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Raum D
Glass D
Carpenter C B
Schur P H
Alper C A
References (22)
22 references, click to expand
  1. On the HLA-B,D map distance.
    Tissue Antigens. 1977 Nov;10(5):394-8 PMID: 146925
  2. Structural heterogeneity of C2 Complement protein and its genetic variants in man: a new polymorphism of the HLA region.
    Proc Natl Acad Sci U S A. 1977 Apr;74(4):1672-5 PMID: 266206
  3. Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):1147-51 PMID: 265561
  4. Very close linkage between HLA-B and Bf inferred from allelic association.
    Nature. 1977 Aug 11;268(5620):527-8 PMID: 889587
  5. Allotypes of complement components in man.
    Transplant Rev. 1976;32:26-42 PMID: 824769
  6. Estimating distances from the centromere by means of benign ovarian teratomas in man.
    Ann Hum Genet. 1976 Nov;40(2):191-6 PMID: 1015813
  7. The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.
    J Clin Invest. 1976 Nov;58(5):1240-8 PMID: 993342
  8. Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf.
    J Exp Med. 1976 Oct 1;144(4):1111-5 PMID: 978135
  9. Inherited deficiency of the second component of complement. Rheumatic disease associations.
    J Clin Invest. 1976 Oct;58(4):853-61 PMID: 965492
  10. Genetic polymorphism in human glycine-rich beta-glycoprotein.
    J Exp Med. 1972 Jan;135(1):68-80 PMID: 4109808
  11. Properdin factor B and histocompatibility loci linked in the rhesus monkey.
    Nature. 1975 Apr 17;254(5501):609-11 PMID: 48198
  12. Association between HLA and cutaneous necrotizing venulitis.
    Arthritis Rheum. 1976 Sep-Oct;19(5):945-9 PMID: 9096
  13. The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):863-4 PMID: 4514997
  14. Linkage of HL-A and GBG.
    Vox Sang. 1974;27(4):382-4 PMID: 4414487
  15. Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
    J Exp Med. 1974 Oct 1;140(4):1108-11 PMID: 4427089
  16. Assignment of the major histocompatibility complex to chromosome No. 6 in a family with a pericentric inversion.
    Hum Hered. 1974;24(3):273-84 PMID: 4435793
  17. Hereditary C2 deficiency: diagnosis and HLA gene complex associations.
    J Immunol. 1976 Apr;116(4):1065-70 PMID: 1082903
  18. Bf maps between the HLA--A and D loci.
    Tissue Antigens. 1976 Feb;7(2):122-4 PMID: 1273828
  19. The Bf locus in the HLA region of chromosome 6: linkage and association studies.
    Humangenetik. 1975 Dec 23;30(4):291-6 PMID: 1218859
  20. The localization of the Bf locus within the MHS region on chromosome no. 6.
    Tissue Antigens. 1976 Jan;7(1):52-4 PMID: 1251438
  21. Hereditary C2 deficiency: Genetic studies and association with the HL-A system.
    J Exp Med. 1975 Jun 1;141(6):1464-9 PMID: 1127385
  22. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.
    Transplantation. 1968 Nov;6(8):913-27 PMID: 5696820
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1979-01-00
Pages
35-41
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685669
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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