Antimicrobial properties of peptides from Xenopus granular gland secretions.

FEBS letters ·Vol. 228 ·No. 2 ·1988-02-15 ·Pages 337-40

Soravia E, Martini G, Zasloff M

Abstract

Previously, we described a family of novel broad spectrum antimicrobial peptides, magainins, from the skin of Xenopus laevis. In this report we show that at least two other Xenopus peptides, present in the skin and its secretions, PGLa and a peptide released from the xenopsin precursor, exhibit antimicrobial properties comparable to the magainins. The identification of these newer members provides insight into the structural diversity of vertebrate antimicrobial peptides.

MeSH Terms

Amino Acid Sequence Animals Anti-Bacterial Agents Antimicrobial Cationic Peptides Bacteria/drug effects Candida albicans/drug effects Escherichia coli/drug effects Fungi/drug effects Magainins Microbial Sensitivity Tests Molecular Sequence Data Peptides/chemical synthesis,pharmacology Protein Conformation Protein Precursors/chemical synthesis,pharmacology Pseudomonas aeruginosa/drug effects Saccharomyces cerevisiae/drug effects Skin/metabolism Staphylococcus aureus/drug effects Streptococcus pyogenes/drug effects Xenopus Proteins Xenopus laevis/metabolism

Chemicals

Anti-Bacterial Agents Antimicrobial Cationic Peptides Magainins Peptides Protein Precursors Xenopus Proteins peptide-Gly-Leu-amide magainin 2 peptide, Xenopus xenopsin precursor fragment (XPF)

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Soravia E

Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Martini G

Zasloff M

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(88)80027-9

Published

1988-02-15

Pages

337-40

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(88)80027-9 View journal details

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Antimicrobial properties of peptides from Xenopus granular gland secretions.

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