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PMID: 3126177 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains.

The Journal of antimicrobial chemotherapy ·Vol. 20 ·No. 6 ·1987-12-00 ·Pages 825-9

Ravizzola G, Pirali F, Paolucci A, Terlenghi L, Peroni L, Colombi A, Turano A

Abstract

Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.

MeSH Terms

Aminoglycosides Animals Anti-Bacterial Agents/pharmacology Ciprofloxacin/pharmacology Drug Resistance, Microbial Female Lethal Dose 50 Male Mice Pseudomonas aeruginosa/drug effects,genetics,pathogenicity Species Specificity Virulence

Chemicals

Aminoglycosides Anti-Bacterial Agents Ciprofloxacin

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Ravizzola G

Institute of Microbiology, University of Brescia, Italy.

Pirali F

Paolucci A

Terlenghi L

Peroni L

Colombi A

Turano A

Article Info

Journal

The Journal of antimicrobial chemotherapy

Abbr.

J Antimicrob Chemother

ISSN

0305-7453

DOI

10.1093/jac/20.6.825

Published

1987-12-00

Pages

825-9

Language

English

Region

England

NLM ID

7513617

Subset

External Links

PubMed source DOI: 10.1093/jac/20.6.825 View journal details

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Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains.

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