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PMID: 3126705 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequence of PSE-2 beta-lactamase.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 1 ·1988-01-00 ·Pages 134-6

Huovinen P, Huovinen S, Jacoby GA

Abstract

The nucleotide sequence of PSE-2 beta-lactamase, an enzyme that readily hydrolyzes both carbenicillin and oxacillin, has been determined. The deduced sequence of 266 amino acids contained 93 residues identical to those of OXA-2 beta-lactamase and the Ser-Thr-Phe-Lys tetrad also found in the active site of TEM-1 beta-lactamase.

MeSH Terms

Amino Acid Sequence Base Sequence DNA, Bacterial/genetics Genes, Bacterial Molecular Sequence Data Pseudomonas aeruginosa/genetics Sequence Homology, Nucleic Acid beta-Lactamases/genetics

Chemicals

DNA, Bacterial beta-lactamase PSE-2 beta-Lactamases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Huovinen P

Massachusetts General Hospital, Boston 02114.

Huovinen S

Jacoby G A

References (15)

15 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.32.1.134

Published

1988-01-00

Pages

134-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC172114

Subset

Grants

NIAID NIH HHS · AI20415 · United States

FIC NIH HHS · FO5 TWO3785 · United States

Databases

GENBANK

J03427

External Links

PubMed source DOI: 10.1128/AAC.32.1.134 PMC Full Text View journal details

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Sequence of PSE-2 beta-lactamase.

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