Antitoxoplasmosis properties of sinefungin in mice.

Sinefungin, an antifungal and antiviral antibiotic, which also has interesting antiparasitic properties, was examined for antitoxoplasma activity. Mice infected with a lethal dose of Toxoplasma gondii trophozoites, when injected daily for 6 days with the antibiotic, starting 2 days after infection, showed significantly increased survival times especially with the highest dose tested (2.5 mg/kg). No overt clinical signs of toxicity due to Sinefungin were observed.