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PMID: 3131427 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A new murine Ig VH gene family.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 140 ·No. 11 ·1988-06-01 ·Pages 4031-4

Kofler R

Abstract

A novel murine VH gene family, termed VH10, has been found and characterized. Based on RFLP analysis, this family exhibits extensive polymorphism among inbred strains of mice and encompasses two to five members, depending on the Igh haplotype. Analyses of recombinant inbred strains suggest a map position of this family 5' to the 7183 and Q52 VH gene families. A VH10 gene has been found to encode anti-DNA autoantibodies from lupus mice; another one may be a pseudogene.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Genes, Immunoglobulin Immunoglobulin Heavy Chains/genetics,isolation & purification Immunoglobulin Variable Region/genetics,isolation & purification Mice Mice, Inbred C57BL Mice, Inbred DBA Molecular Sequence Data Nucleotide Mapping Recombination, Genetic Sequence Homology, Nucleic Acid

Chemicals

Immunoglobulin Heavy Chains Immunoglobulin Variable Region

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kofler R

Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1988-06-01

Pages

4031-4

Language

English

Region

United States

NLM ID

2985117R

Subset

Grants

NIAID NIH HHS · AI07007 · United States

NIAMS NIH HHS · AR31203 · United States

NIAMS NIH HHS · AR33826 · United States

Databases

GENBANK

M20825, M21470

External Links

PubMed source View journal details

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A new murine Ig VH gene family.

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