Comparative in vitro activity of the new quinolone fleroxacin (RO 23-6240).

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 7 ·No. 1 ·1988-02-00 ·Pages 63-6

Verschraegen G, Claeys G, Van den Abeele AM

Abstract

RO 23-6240 (fleroxacin), pefloxacin, augmentin, cefaclor, cef-uroxime, ceftazidime, vancomycin, piperacillin and amikacin were tested against a wide variety of gram-positive and gram-negative bacteria. The MICs of fleroxacin were very similar to those of pefloxacin. Against all the bacterial groups tested, the quinolones compared favorably with the other antimicrobials tested, particularly against the more resistant species such as Corynebacterium group JK and D2 and methicillin-resistant staphylococci.

MeSH Terms

Amikacin/pharmacology Amoxicillin/pharmacology Amoxicillin-Potassium Clavulanate Combination Anti-Bacterial Agents/pharmacology Bacteria/drug effects Cefaclor/pharmacology Ceftazidime/pharmacology Cefuroxime/pharmacology Ciprofloxacin/analogs & derivatives,pharmacology Clavulanic Acids/pharmacology Corynebacterium/drug effects Drug Combinations/pharmacology Drug Resistance, Microbial Fleroxacin Norfloxacin/analogs & derivatives,pharmacology Pefloxacin Piperacillin/pharmacology Staphylococcus/drug effects Vancomycin/pharmacology

Chemicals

Anti-Bacterial Agents Clavulanic Acids Drug Combinations Pefloxacin Ciprofloxacin Cefaclor Vancomycin Amoxicillin-Potassium Clavulanate Combination Amoxicillin Amikacin Ceftazidime Norfloxacin Fleroxacin Cefuroxime Piperacillin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Verschraegen G

Department of Medical Microbiology, State University of Ghent, University Hospital, Belgium.

Claeys G

Van den Abeele A M

References (7)

7 references, click to expand

Activity of ciprofloxacin against multiply resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, and group JK corynebacteria.
Antimicrob Agents Chemother. 1986 Dec;30(6):940-1 PMID: 3101589
In vitro activity of the new 4-quinolone compound Ro 23-6240.
Eur J Clin Microbiol. 1987 Apr;6(2):161-4 PMID: 3109895
In vitro activity of Ro 23-6240, a new fluorinated 4-quinolone.
Antimicrob Agents Chemother. 1986 Apr;29(4):675-80 PMID: 3085584
The in-vitro activity of ciprofloxacin compared with that of norfloxacin and nalidixic acid.
J Antimicrob Chemother. 1984 Apr;13(4):325-31 PMID: 6233249
Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone.
Antimicrob Agents Chemother. 1987 Feb;31(2):161-3 PMID: 3105446
In-vitro activity of pefloxacin against micro-organisms multiply resistant to beta-lactam antibiotics and aminoglycosides.
J Antimicrob Chemother. 1986 Apr;17 Suppl B:11-7 PMID: 3086278
The comparative in-vitro activity of pefloxacin.
J Antimicrob Chemother. 1986 Apr;17 Suppl B:1-10 PMID: 2940213

Article Info

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Abbr.

Eur J Clin Microbiol Infect Dis

ISSN

0934-9723

DOI

10.1007/BF01962177

Published

1988-02-00

Pages

63-6

Language

English

Region

Germany

NLM ID

8804297

Subset

External Links

PubMed source DOI: 10.1007/BF01962177 View journal details

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Comparative in vitro activity of the new quinolone fleroxacin (RO 23-6240).

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