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PMID: 3132953 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

HIV-2 antisera cross-neutralize HIV-1.

AIDS (London, England) ·Vol. 2 ·No. 2 ·1988-04-00 ·Pages 95-100

Weiss RA, Clapham PR, Weber JN, Whitby D, Tedder RS, O'Connor T, Chamaret S, Montagnier L

Abstract

The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.

MeSH Terms

Antibodies, Viral/physiology Antibody Specificity Cross Reactions Enzyme-Linked Immunosorbent Assay HIV/immunology HIV Antibodies Humans Immune Sera/pharmacology Neutralization Tests/methods Precipitin Tests

Chemicals

Antibodies, Viral HIV Antibodies Immune Sera

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Weiss R A

Chester Beatty Laboratories, Institute of Cancer Research, London, UK.

Clapham P R

Weber J N

Whitby D

Tedder R S

O'Connor T

Chamaret S

Montagnier L

Article Info

Journal

AIDS (London, England)

Abbr.

AIDS

ISSN

0269-9370

DOI

10.1097/00002030-198804000-00004

Published

1988-04-00

Pages

95-100

Language

English

Region

England

NLM ID

8710219

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1097/00002030-198804000-00004 View journal details

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