Nitrogen source regulates glutamine synthetase mRNA levels in Neurospora crassa.
Neurospora crassa glutamine synthetase mRNA was measured by its capacity to direct the synthesis of the specific protein in a cell-free system derived from rabbit reticulocytes. N. crassa cultures grown on glutamate as the sole nitrogen source had higher mRNA activities than did those grown on glutamine. The differences were about 10-fold when polysomal RNA was used for translation and about 5-fold when either total cellular RNA or polyadenylic acid-enriched cellular RNA was used. These data indicate that in exponentially growing N. crassa, the nitrogen source regulates glutamine synthetase by adjusting specific mRNA levels.
19 references, click to expand
-
The regulation of glutamine metabolism in Candida utilis: the role of glutamine in the control of glutamine synthetase.J Gen Microbiol. 1974 Jan;80(1):159-71 PMID: 4150659
-
RNA synthesis in plant leaf tissue: the characterization of messenger RNA species lacking and containing polyadenylic acid.J Mol Biol. 1976 Dec 15;108(3):595-608 PMID: 1018319
-
Regulatory mechanisms in the induction of glutamine synthetase in the embryonic retina: immunochemical studies.Dev Biol. 1972 May;28(1):229-41 PMID: 4402760
-
Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate.J Biol Chem. 1972 Sep 10;247(17):5312-21 PMID: 4403443
-
Regulation of glutamine synthetase in cultured Chinese hamster cells. Induction and repression by glutamine.J Biol Chem. 1972 Sep 25;247(18):5722-7 PMID: 4403489
-
Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate.J Biol Chem. 1973 Mar 25;248(6):2095-106 PMID: 4690593
-
Regulation of synthesis of glutamate dehydrogenase and glutamine synthetase in micro-organisms.Biochem J. 1969 Dec;115(4):769-75 PMID: 4901826
-
ON THE GLUTAMATE-PROLINE-ORNITHINE INTERRELATION IN NEUROSPORA CRASSA.Proc Natl Acad Sci U S A. 1954 Aug;40(8):688-94 PMID: 16589539
-
Pea leaf glutamine synthetase: regulatory properties.Plant Physiol. 1975 Jun;55(6):968-74 PMID: 16659228
-
Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase.Proc Natl Acad Sci U S A. 1975 Dec;72(12):4844-8 PMID: 1744
-
Messenger RNA for glutamine synthetase: its partial purification, translation in a cell-free system and its regulation by hydrocortisone.Biochem Biophys Res Commun. 1976 Feb 9;68(3):675-81 PMID: 4066
-
Neurospora crassa glutamine synthetase. Purification by affinity chromatography and characterization of subunit structure.J Biol Chem. 1976 Aug 10;251(15):4787-91 PMID: 7567
-
Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.Cell. 1976 May;8(1):95-101 PMID: 8212
-
Regulation of glnA messinger ribonucleic acid synthesis in Klebsiella aerogenes.J Bacteriol. 1977 Feb;129(2):880-7 PMID: 14114
-
Neurospora crassa glutamine synthetase. Translation of specific messenger ribonucleic acid in a cell-free system derived from rabbit reticulocytes.J Biol Chem. 1977 May 10;252(9):3028-34 PMID: 16013
-
Regulation of glutamine synthetase in fed-batch cultures of Neurospora crassa.Biochem Biophys Res Commun. 1977 Oct 24;78(4):1234-40 PMID: 21661
-
Neurospora crassa glutamine synthetase. Role of enzyme synthesis and degradation on the regulation of enzyme concentration during exponential growth.J Biol Chem. 1977 Dec 10;252(23):8724-7 PMID: 21883
-
Cascade control of Escherichia coli glutamine synthetase. Properties of the PII regulatory protein and the uridylyltransferase-uridylyl-removing enzyme.J Biol Chem. 1975 Aug 25;250(16):6264-72 PMID: 239942
-
Clonal differences in glutamine synthetase activity of hepatoma cells. Effects of glutamine and dexamethasone.J Cell Biol. 1972 Jul;54(1):175-9 PMID: 4402645
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
