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PMID: 3137575 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 18 ·1988-09-00 ·Pages 6890-4

Hermanson GG, Eisenberg D, Kincade PW, Wall R

Abstract

A number of the glycoproteins identified on the surfaces of cells of the immune response belong to the immunoglobulin superfamily. We have isolated and characterized cDNA clones and the complete genomic gene encoding a B-cell-specific member of the immunoglobulin superfamily called "B29." This isolate is expressed at all stages in B-cell development beginning with the earliest precursor B cells undergoing immunoglobulin heavy chain gene diversity region----joining region gene (DH----JH) rearrangements. The protein sequence predicted by the B29 coding region contains a leader sequence and a single extracellular immunoglobulin-like domain, followed by a hydrophobic transmembrane segment and a charged intracytoplasmic domain. The immunoglobulin-like domain contains cysteines and other conserved amino acids characteristic of light chain variable and joining regions, but overall the sequence is only distantly related to immunoglobulins. Each of these domains is encoded in separate exons in the B29 gene, in analogy to other members of the immunoglobulin superfamily. The conserved structural features of the immunoglobulin-like domain in the B29 gene product resemble those of other members of the immunoglobulin superfamily involved in cell recognition and adhesion.

MeSH Terms
Amino Acid Sequence Antibody Formation B-Lymphocytes/analysis Base Sequence Cell Line Cloning, Molecular DNA/analysis Humans Immunoglobulin Heavy Chains/genetics Immunoglobulin J-Chains/genetics Immunoglobulins/genetics Molecular Sequence Data
Chemicals
Immunoglobulin Heavy Chains Immunoglobulin J-Chains Immunoglobulins DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hermanson G G
Molecular Biology Institute, University of California, Los Angeles 90024.
Eisenberg D
Kincade P W
Wall R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.18.6890
Published
1988-09-00
Pages
6890-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC282084
Subset
IM
Grants
NIAID NIH HHS · AI 20069 · United States
NCI NIH HHS · CA 09056-11 · United States
NCI NIH HHS · CA 12800 · United States
Databases
GENBANK
J03857
External Links
PubMed source DOI: 10.1073/pnas.85.18.6890 PMC Full Text View journal details
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