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PMID: 3143074 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Unresponsiveness to a foreign antigen can be caused by self-tolerance.

Nature ·Vol. 336 ·No. 6196 ·1988-11-17 ·Pages 222-5

Vidović D, Matzinger P

Abstract

In mice, two sets of genes govern the immune response to the synthetic antigen GT. One maps to the major histocompatibility complex and behaves like a typical immune response gene. The second is a background gene encoding a cell surface structure found on B cells. Mice which express, and are therefore tolerant of, one form of this structure do not respond to GT. Thus, tolerance of self generates holes in the T-cell repertoire, partially crippling the immune system.

MeSH Terms

Animals Antigens/immunology Autoantigens/immunology B-Lymphocytes/immunology Chromosome Mapping Gene Expression Regulation Genes, MHC Class II Immune Tolerance Intercellular Signaling Peptides and Proteins Lipopolysaccharides/pharmacology Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred DBA Peptides/immunology T-Lymphocytes/immunology

Chemicals

Antigens Autoantigens Intercellular Signaling Peptides and Proteins Lipopolysaccharides Peptides L-glutamic acid-L-tyrosine copolymer

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Vidović D

Basel Institute for Immunology, Switzerland.

Matzinger P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/336222a0

Published

1988-11-17

Pages

222-5

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/336222a0 View journal details

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Unresponsiveness to a foreign antigen can be caused by self-tolerance.

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