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PMID: 3147218 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A linkage map of mouse chromosome 12: localization of Igh and effects of sex and interference on recombination.

Genetics ·Vol. 120 ·No. 4 ·1988-12-00 ·Pages 1073-83

Blank RD, Campbell GR, Calabro A, D'Eustachio P

Abstract

Inheritance of restriction fragment length polymorphisms associated with four anonymous DNA markers (D12Nyu1, 2, 3 and 4), the Fos proto-oncogene, the Mtv-9 viral integration site, and the alpha 1-antitrypsin (Aat-1) and immunoglobulin heavy chain (Igh) gene families in the mouse has been followed in a backcross experiment. A Bayesian multilocus map-building strategy yielded the map: centromere-D12Nyu2-10 cM-D12Nyu1-2 cM-D12Nyu3-15 cM-Fos-1 cM-D12Nyu4-2 cM-Mtv-9-8 cM-Aat-1-17 cM-Igh-C. A map constructed from male meiotic data was substantially shorter than one constructed from female meiotic data. Significant interference was observed for the linkage group. Two groups of markers studied in recombinant inbred strains of mice could be interpolated into the map: Es-25, D12Nyu10, D12Nyu7 and Apob form a cluster proximal to D12Nyu2, and Ly-18, Ah, and D12Nyu5 form a cluster between D12Nyu2 and D12Nyu1. These data establish an unambiguously ordered linkage group including Igh and Aat-1 that spans most of chromosome 12.

MeSH Terms
Algorithms Animals Chromosome Mapping Crosses, Genetic Data Interpretation, Statistical Female Genetic Linkage Immunoglobulin Heavy Chains/genetics Male Mice Mice, Inbred Strains Proto-Oncogenes Recombination, Genetic Sex Factors alpha 1-Antitrypsin/genetics
Chemicals
Immunoglobulin Heavy Chains alpha 1-Antitrypsin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Blank R D
Department of Biochemistry, New York University Medical Center, New York 10016.
Campbell G R
Calabro A
D'Eustachio P
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19 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/120.4.1073
Published
1988-12-00
Pages
1073-83
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1203570
Subset
IM
Grants
NIGMS NIH HHS · GM32105 · United States
External Links
PubMed source DOI: 10.1093/genetics/120.4.1073 PMC Full Text View journal details
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