Home LiteratureArticle Details
PMID: 314784 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins.

Annals of the rheumatic diseases ·Vol. 38 ·No. 3 ·1979-06-00 ·Pages 257-61

McIntosh RM, Rabideau D, Allen JE, Garcia R, Rubio L, Carr RI, Rodriguez-Iturbe B

Abstract

Antiglobulins were measured in the sera of 82 patients with acute poststreptococcal glomerulonephritis and correlated with C1q binding activity, serum levels of immunoglobulins and C3, site of infection, antibody titres to streptococcal enzymes, and the duration of the nephritis and interval from infection. Raised serum antiglobulins were found in 89.2% of the patients. In addition, raised titres were detected at any time during the course of the disease and very early after streptococcal infection. The finding of antiglobulins soon after the infection suggests the possibility that they appear as a primary event in the disease.

MeSH Terms
Acute Disease Adolescent Adult Antibodies, Anti-Idiotypic/analysis Child Child, Preschool Glomerulonephritis/etiology,immunology Humans Immunoglobulins/analysis,immunology Rheumatoid Factor/analysis Streptococcal Infections/complications Time Factors
Chemicals
Antibodies, Anti-Idiotypic Immunoglobulins Rheumatoid Factor
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
McIntosh R M
Rabideau D
Allen J E
Garcia R
Rubio L
Carr R I
Rodriguez-Iturbe B
References (21)
21 references, click to expand
  1. STUDIES ON THE PATHOGENESIS OF ACUTE AND PROGRESSIVE GLOMERULONEPHRITIS IN MAN BY IMMUNOFLUORESCEIN AND IMMUNOFERRITIN TECHNIQUES.
    Fed Proc. 1965 Jan-Feb;24:100-8 PMID: 14278990
  2. Renal localization of antiglobulins in glomerulonephritis and after renal transplantation.
    Arthritis Rheum. 1977 May;20(4):947-61 PMID: 324484
  3. Antiglobulins in juvenile rheumatoid arthritis.
    Arthritis Rheum. 1977 Mar;20(2):729-35 PMID: 322670
  4. Demonstration of antigenic sites in glomeruli of patients with acute poststreptococcal glomerulonephritis by immunofluorescein and immunoferritin technics.
    Am J Pathol. 1973 Jan;70(1):131-50 PMID: 4118883
  5. Immune complex systems in the nephritis of systemic lupus erythematosus.
    Kidney Int. 1973 Feb;3(2):90-9 PMID: 4121101
  6. Acute poststreptococcal glomerulonephritis: immune deposit disease.
    J Clin Invest. 1966 Feb;45(2):237-48 PMID: 4159050
  7. Immunologically mediated glomerular, tubular and interstitial renal disease.
    N Engl J Med. 1973 Mar 15;288(11):564-70 PMID: 4119561
  8. Mixed cryoglobulins and glomerulonephritis.
    Ann Intern Med. 1968 Dec;69(6):1221-7 PMID: 4177812
  9. Occurrence of 19S and 7S anti-IgGs during hyperimmunization of rabbits with streptococci.
    J Exp Med. 1972 Oct 1;136(4):799-815 PMID: 4403474
  10. Rheumatoid factor in acute bacterial endocarditis.
    Arthritis Rheum. 1976 Sep-Oct;19(5):887-90 PMID: 962970
  11. Streptococcus-related glomerulonephritis.
    Kidney Int. 1973 Feb;3(2):100-4 PMID: 4576694
  12. Renal involvement in essential cryoglobulinaemia.
    Acta Med Scand. 1973;194(3):229-36 PMID: 4583533
  13. Editorial: Acute poststreptococcal glomerulonephritis. Mechanism and sequelae--attempts at a unifying concept.
    Clin Nephrol. 1972 Mar-Apr;1(2):55-60 PMID: 4593114
  14. Glomerular lesions produced by autologous serum and autologous IgG modified by treatment with a culture of a -haemolytic streptooccus.
    J Med Microbiol. 1972 Feb;5(1):1-7 PMID: 4553907
  15. Alteration of the chemical composition of human immunoglobulin G by Streptococcus pyogenes.
    J Med Microbiol. 1971 Nov;4(4):535-8 PMID: 5002689
  16. Cryoglobulins. II. The biological and chemical properties of cryoproteins in acute post-streptococcal glomerulonephritis.
    Int Arch Allergy Appl Immunol. 1971;41(5):700-15 PMID: 5005896
  17. On the nature of cryoglobulins.
    J Immunol. 1968 Mar;100(3):594-603 PMID: 4966841
  18. Cryoglobulins. I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis.
    J Lab Clin Med. 1970 Apr;75(4):566-77 PMID: 4910479
  19. The kidney in progressive systemic sclerosis: immunohistochemical and antibody elution studies.
    Lab Invest. 1976 Aug;35(2):124-31 PMID: 785092
  20. Cryoglobulins. III. Further studies on the nature, incidence, clinical, diagnostic, prognostic, and immunopathologic significance of cryoproteins in renal disease.
    Q J Med. 1975 Apr;44(174):285-307 PMID: 1101284
  21. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease.
    J Clin Invest. 1976 May;57(5):1308-19 PMID: 944196
Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.38.3.257
Published
1979-06-00
Pages
257-61
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1000448
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.38.3.257 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2