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PMID: 3170773 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Prognostic indicators in centroblastic-centrocytic lymphoma.

Journal of clinical pathology ·Vol. 41 ·No. 8 ·1988-08-00 ·Pages 866-70

Griffin NR, Howard MR, Quirke P, O'Brien CJ, Child JA, Bird CC

Abstract

The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.

MeSH Terms
Adult Aged Aged, 80 and over Cell Count DNA, Neoplasm/analysis Female Flow Cytometry Humans Lymphoma, Non-Hodgkin/mortality,pathology Male Middle Aged Mitosis Prognosis Time Factors
Chemicals
DNA, Neoplasm
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Griffin N R
Department of Pathology, University of Leeds.
Howard M R
Quirke P
O'Brien C J
Child J A
Bird C C
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.41.8.866
Published
1988-08-00
Pages
866-70
Language
English
Region
England
NLM ID
0376601
PMCID
PMC1141617
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.41.8.866 PMC Full Text View journal details
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