A clinical comparative study of ofloxacin and pivampicillin in acute exacerbations of chronic bronchitis.

A controlled clinical study employing a double-blind, double-dummy technique was carried out on 84 patients with purulent exacerbations of chronic bronchitis. Ofloxacin (200 mg x 2 daily) and pivampicillin (700 mg x 3 daily), were compared for efficacy, safety, and adverse reactions. Both regimens had high bacteriological elimination rates (94.1, 97.2%) and clinical cure rates (97.4, 97.6%). However, there were fewer adverse reactions and a greater patient acceptance in the ofloxacin treated group.