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PMID: 31839815 Published · epublish English Journal Article

Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma.

Journal of Cancer ·Vol. 10 ·No. 27 ·2019-00-00 ·Pages 6813-6821

Namani A, Zheng Z, Wang XJ, Tang X

Abstract

Mutations in KEAP1 and/or NRF2 genes have been identified across many cancers and the dysregulation of the NRF2 pathway due to these mutations leads to drug and radioresistance in several cancers. Identification of biomarkers associated with these mutations allows the researchers and clinicians to identify the personalized medicine and quicker diagnosis. In this current study, we carried out an integrated, multi-omics, multi-database analysis of exome, transcriptomics data's of KEAP1 mutated TCGA- Lung adenocarcinoma (LUAD) patients against non-mutated counterparts. Finally, we discovered the gene signature associated with KEAP1 mutations, prognostic genes which were highly correlated with the upregulation of the NRF2 pathway in the KEAP1 mutated LUAD patients. Our finding might be useful to identify the early diagnosis of KEAP1 mutated LUAD patients.

Keywords
KEAP1 mutations NRF2 biomarkers gene signature TCGA-Lung adenocarcinoma
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Namani Akhileshwar
Department of Thoracic Surgery and Department of Biochemistry of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR China.
Zheng Zhaohong
Department of Pharmacology, and Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, PR China.
Wang Xiu Jun
Department of Pharmacology, and Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, PR China.
Tang Xiuwen
Department of Thoracic Surgery and Department of Biochemistry of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR China.
Conflict of Interest

Competing Interests: The authors have declared that no competing interest exists.

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Article Info
Journal
Journal of Cancer
Abbr.
J Cancer
ISSN
1837-9664
DOI
10.7150/jca.35489
Published
2019-00-00
Epub
2019-00-01
Pages
6813-6821
Language
English
Region
Australia
NLM ID
101535920
PMCID
PMC6909944
External Links
PubMed source DOI: 10.7150/jca.35489 PMC Full Text View journal details
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