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PMID: 3185116 Published · ppublish English Journal Article

Phospholipid analysis of human eosinophils: high levels of alkylacylglycerophosphocholine (PAF precursor).

Lipids ·Vol. 23 ·No. 8 ·1988-08-00 ·Pages 815-7

Ojima-Uchiyama A, Masuzawa Y, Sugiura T, Waku K, Saito H, Yui Y, Tomioka H

Abstract

The phospholipid composition and fatty acid profiles of human eosinophils were studied. Extremely high levels of ether phospholipids were found in this type of cell, such as alkylacylglycerophosphocholine (GPC) and alkenylacylglycerophosphoethanolamine (GPE); these two ether phospholipids accounted for about three-fourths of the choline and ethanolamine glycerophospholipids (CGP and EGP), respectively. Fatty acid analyses revealed that very large portions of arachidonic acid (20:4) were esterified to alkylacyl-GPC (92.0% in CGP) and alkenylacyl-GPE (86.6% in EGP), respectively. While high amounts of alkylacyl-GPC and the abundance of 20:4 in this ether phospholipid have been observed in other types of blood cells of various animals, these percentages for human eosinophils are the highest among such cells. These results suggest that alkyl and alkenyl ether phospholipids play essential roles in human eosinophils in various physiological and pathological conditions.

MeSH Terms
Eosinophils/analysis Fatty Acids/analysis Humans Neutrophils/analysis Phosphatidylcholines/analysis Phosphatidylethanolamines/analysis Phospholipids/analysis Platelet Activating Factor/analogs & derivatives,analysis
Chemicals
1-alkyl-2-acyl-sn-glycero-3-phosphocholine Fatty Acids Phosphatidylcholines Phosphatidylethanolamines Phospholipids Platelet Activating Factor
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Ojima-Uchiyama A
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Masuzawa Y
Sugiura T
Waku K
Saito H
Yui Y
Tomioka H
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24 references, click to expand
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Article Info
Journal
Lipids
Abbr.
Lipids
ISSN
0024-4201
DOI
10.1007/BF02536227
Published
1988-08-00
Pages
815-7
Language
English
Region
United States
NLM ID
0060450
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02536227 View journal details
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